Alkane Carbon-Hydrogen Bond Functionalization with (NHC)MCl Precatalysts (M = Cu, Au; NHC = N-Heterocyclic Carbene)

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• 作者：Manuel R. Fructos ; Pierre de Fré ; mont ; Steven P. Nolan ; M. Mar D&iacute ; az-Requejo ; and Pedro J. Pé ; rez
• 刊名：Organometallics
• 出版年：2006
• 出版时间：April 24, 2006
• 年：2006
• 卷：25
• 期：9
• 页码：2237 - 2241
• 全文大小：109K
• 年卷期：v.25,no.9(April 24, 2006)
• ISSN：1520-6041

文摘

Facile alkane functionalization by means of the insertion of :CHCO₂Et, from ethyl diazoacetate, intocarbon-hydrogen bonds mediated by catalytic amounts of (NHC)MCl (NHC = N-heterocyclic ligand;M = Cu, Au) and a halide scavenger MX has been achieved. This chemistry includes the insertion of thecarbene fragment into alkane primary positions with Cu- and Au-based catalysts. The nature of thecounterion X and of the NHC ligand have a significant effect on the overall yields and regioselectivityof the reaction.