Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy -Lactam Derivatives from Amino Acids

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• 作者：Paula Pé ; rez-Faginas ; Fran O'Reilly ; Aisling O'Byrne ; Carlos Garc&iacute ; a-Aparicio ; Mercedes Mart&iacute ; n-Mart&iacute ; nez ; M. Jesú ; s Pé ; rez de Vega ; M. Teresa Garc&iacute ; a-L&oacut
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：April 12, 2007
• 年：2007
• 卷：9
• 期：8
• 页码：1593 - 1596
• 全文大小：104K
• 年卷期：v.9,no.8(April 12, 2007)
• ISSN：1523-7052

文摘

The base-promoted cyclization of optically pure N-(p-methoxybenzyl)-N-(2-chloro)propionyl amino acid derivatives resulted in a diastereo- andenantioselective approach to valuable 1,3,4,4-tetrasubstituted -lactams. The stereochemical outcome of the reaction is exclusively governedby the configuration of the N-(2-chloro)propionyl moiety.