Simple and Efficient Heterogeneous Copper Catalysts for Enantioselective C-H Carbene Insertion

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• 作者：José ; M. Fraile ; José ; I. Garc&iacute ; a ; José ; A. Mayoral ; Marta Roldá ; n
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：February 15, 2007
• 年：2007
• 卷：9
• 期：4
• 页码：731 - 733
• 全文大小：45K
• 年卷期：v.9,no.4(February 15, 2007)
• ISSN：1523-7052

文摘

Immobilized box-Cu complexes are able to efficiently catalyze the insertion of a carbene, from methyl phenyldiazoacetate, into C-H bonds ofTHF, with high enantioselectivity (up to 88% ee). The immobilization not only allows recovery and reuse of the enantioselective catalyst butalso provides an improvement in the selectivities from the values obtained in solution, probably due to a confinement effect of the bidimensionalsupport.