文摘
Sixteen new 7,7-dialkyl-5-hydroxymethyl-6-oxabicyclo[3.2.1]octane-1-carboxylic acid amide derivatives with thehydroxymethyl and the N-alkylamide functional groups in axial positions have been synthesized, and the solid-state structure of 10of them has been determined. All of them crystallized as anhydrous compounds, and the conformation of the hydroxyl and N-alkylamidesubstituents was found to be correlated with the types of interactions in which they are involved, generating two- and three-dimensionalhydrogen-bonding networks based on identical dimeric substructures in 8 of the 10 cases. This dimer can be considered as asupramolecular synthon for future crystal engineering studies.