Antimalarial 4-Phenylcoumarins from the Stem Bark of Hintonia latiflora
详细信息 查看全文
- 作者：Rocí ; o Argotte-Ramos ; Guillermo Ramí ; rez-Avila ; Marí ; a del Carmen Rodrí ; guez-Gutié ; rrez ; Marbella Ovilla-Muñ ; oz ; Humberto Lanz-Mendoza ; Mario H. Rodrí ; guez ; M
- 刊名：Journal of Natural Products
- 出版年：2006
- 出版时间：October 2006
- 年：2006
- 卷：69
- 期：10
- 页码：1442 - 1444
- 全文大小：41K
- 年卷期：v.69,no.10(October 2006)
- ISSN：1520-6025
文摘
The EtOAc extract of the stem bark of Hintonia latiflora showed the suppression of total parasitemia and thechemosuppression of schizont numbers, when tested in vivo against Plasmodium berghei infection in mice. Bioassay-directed fractionation of the EtOAc extract, using the in vitro 16 h and the in vivo 4-day suppression tests on P. bergheischizont numbers, led to the isolation of the new compound 5-O-
-D-glucopyranosyl-7,4'-dimethoxy-3'-hydroxy-4-phenylcoumarin (1), along with the known 5-O--D-glucopyranosyl-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin (2).The structure of compound 1 was established on the basis of spectroscopic data interpretation. Compounds 1 and 2suppressed the development of P. berghei schizonts in vitro with IC50 values of 24.7 and 25.9 
M, respectively. Compound2 suppressed the development of schizonts at the dose of 40 mg/kg by 70.8% in the in vivo assay.
-D-glucopyranosyl-7,4'-dimethoxy-3'-hydroxy-4-phenylcoumarin (1), along with the known 5-O--D-glucopyranosyl-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin (2).The structure of compound 1 was established on the basis of spectroscopic data interpretation. Compounds 1 and 2suppressed the development of P. berghei schizonts in vitro with IC50 values of 24.7 and 25.9 M, respectively. Compound2 suppressed the development of schizonts at the dose of 40 mg/kg by 70.8% in the in vivo assay.