Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes
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- 作者：P盲r G. Janson ; Ibrahim Ghoneim ; Nadia O. Ilchenko ; K谩lm谩n J. Szab贸
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：June 1, 2012
- 年：2012
- 卷：14
- 期：11
- 页码：2882-2885
- 全文大小：199K
- 年卷期：v.14,no.11(June 1, 2012)
- ISSN：1523-7052
文摘
Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of CuI, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction.