Sulfur-Specific Detection of Impurities in Cimetidine Drug Substance Using Liquid Chromatography Coupled to High Resolution Inductively Coupled Plasma Mass Spectrometry and Electrospray Mass Spectrome

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• 作者：E. Hywel Evans ; Jean-Claude Wolff ; and Christine Eckers
• 刊名：Analytical Chemistry
• 出版年：2001
• 出版时间：October 1, 2001
• 年：2001
• 卷：73
• 期：19
• 页码：4722 - 4728
• 全文大小：99K
• 年卷期：v.73,no.19(October 1, 2001)
• ISSN：1520-6882

文摘

The use of liquid chromatography coupled to sector fieldinductively coupled plasma mass spectrometry (SF-ICP-MS) for the specific detection of sulfur-containing compounds is described. In the sulfur-containing drug substance cimetidine, structurally related impurities wellbelow the 0.1% mass fraction level relative to the maindrug substance could easily be detected. The structureof most of the impurities was confirmed by electrospraymass spectrometry (ESI-MS), and thus, the complementarity of the two techniques for drug analysis is shown.The limit of detection by SF-ICP-MS for cimetidine insolution was ~4-20 ng·g^-1, but it was blank-limited.