Biocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles

详细信息    查看全文

• 作者：Jessica D. Schiffman ; Yue Wang ; Emmanuel P. Giannelis ; Menachem Elimelech
• 刊名：Langmuir
• 出版年：2011
• 出版时间：November 1, 2011
• 年：2011
• 卷：27
• 期：21
• 页码：13159-13164
• 全文大小：912K
• 年卷期：v.27,no.21(November 1, 2011)
• ISSN：1520-5827

文摘

The incorporation of silver nanoparticles (AgNPs) into polymeric nanofibers has attracted a great deal of attention due to the strong antimicrobial activity that the resulting fibers exhibit. However, bactericidal efficacy of AgNP-coated electrospun fibrous mats has not yet been demonstrated. In this study, polysulfone (PSf) fibers were electrospun and surface-modified using an oxygen plasma treatment, which allowed for facile irreversible deposition of cationically charged polyethyleneimine (PEI)-AgNPs via electrostatic interactions. The PSf鈥揂gNP mats were characterized for relative silver concentration as a function of plasma treatment time using ICP-MS and changes in contact angle. Plasma treatment of 60 s was the shortest time required for maximum loss of bacteria (Escherichia coli) viability. Time-dependent bacterial cytotoxicity studies indicate that the optimized PSf鈥揂gNP mats exhibit a high level of inactivation against both Gram negative bacteria, Escherichia coli, and Gram positive bacteria, Bacillus anthracis and Staphylococcus aureus.