Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp.

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• 作者：Yasuhiro Igarashi ; Youngju Kim ; Yasuko In ; Toshimasa Ishida ; Yukiko Kan ; Tsuyoshi Fujita ; Takashi Iwashita ; Hirokazu Tabata ; Hiroyasu Onaka ; Tamotsu Furumai
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：August 6, 2010
• 年：2010
• 卷：12
• 期：15
• 页码：3402-3405
• 全文大小：180K
• 年卷期：v.12,no.15(August 6, 2010)
• ISSN：1523-7052

文摘

Alchivemycin A, a novel polycyclic polyketide, was isolated from the culture extract of a plant-derived actinomycete Streptomyces sp. The structure and relative configuration were elucidated by spectroscopic analysis and X-ray crystallography, and the absolute configuration was determined by a ¹H NMR anisotropy method using MPA ester derivatization. The new compound contains an unprecedented heterocyclic ring system, 2H-tetrahydro-4,6-dioxo-1,2-oxazine. Alchivemycin A showed potent antimicrobial activity against Micrococcus luteus and inhibitory effects on tumor cell invasion.