Akaeolide, a Carbocyclic Polyketide from Marine-Derived Streptomyces

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• 作者：Yasuhiro Igarashi ; Tao Zhou ; Seizo Sato ; Takashi Matsumoto ; Linkai Yu ; Naoya Oku
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：15
• 期：22
• 页码：5678-5681
• 全文大小：233K
• 年卷期：v.15,no.22(November 15, 2013)
• ISSN：1523-7052

文摘

Akaeolide, a novel polycyclic polyketide, was isolated from the culture extract of a marine-derived actinomycete belonging to the genus Streptomyces. The planar structure of the new compound was elucidated by spectroscopic analysis including NMR and MS, and the absolute configuration was determined by X-ray crystallographic analysis of its chlorinated derivative. Akaeolide possesses a 15-membered carbocyclic framework, apparently derived from the malonate pathway, with a tetrahydrofuran ring and a 尾-keto-未-lactone unit.