Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes
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- 作者：Javier Francos ; Francisca Grande-Carmona ; H茅lio Faustino ; Javier Iglesias-Sig眉enza ; Elena D铆ez ; Isaac Alonso ; Rosario Fern谩ndez ; Jos茅 M. Lassaletta ; Fernando L贸pez ; Jos茅 L. Mascare帽as
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：September 5, 2012
- 年：2012
- 卷：134
- 期：35
- 页码：14322-14325
- 全文大小：340K
- 年卷期：v.134,no.35(September 5, 2012)
- ISSN：1520-5126
文摘
The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and up to three stereocenters. Key to the success of the process is the use of newly designed axially chiral N-heterocyclic carbene鈥揼old catalysts.