Graphene Oxide Nanosheets Reshape Synaptic Function in Cultured Brain Networks

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• 作者：Rossana Rauti ; Neus Lozano ; Veronica León ; Denis Scaini ; Mattia Musto ; Ilaria Rago ; Francesco P. Ulloa Severino ; Alessandra Fabbro ; Loredana Casalis ; Ester Vázquez ; Kostas Kostarelos ; Maurizio Prato ; Laura Ballerini
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：April 26, 2016
• 年：2016
• 卷：10
• 期：4
• 页码：4459-4471
• 全文大小：593K
• 年卷期：0
• ISSN：1936-086X

文摘

Graphene offers promising advantages for biomedical applications. However, adoption of graphene technology in biomedicine also poses important challenges in terms of understanding cell responses, cellular uptake, or the intracellular fate of soluble graphene derivatives. In the biological microenvironment, graphene nanosheets might interact with exposed cellular and subcellular structures, resulting in unexpected regulation of sophisticated biological signaling. More broadly, biomedical devices based on the design of these 2D planar nanostructures for interventions in the central nervous system require an accurate understanding of their interactions with the neuronal milieu. Here, we describe the ability of graphene oxide nanosheets to down-regulate neuronal signaling without affecting cell viability.