Highly Efficient One-Pot Synthesis of N-Sulfonylamidines by Cu-Catalyzed Three-Component Coupling of Sulfonyl Azide, Alkyne, and Amine

详细信息    查看全文

• 作者：Imhyuck Bae ; Hoon Han ; and Sukbok Chang
• 刊名：Journal of the American Chemical Society
• 出版年：2005
• 出版时间：February 23, 2005
• 年：2005
• 卷：127
• 期：7
• 页码：2038 - 2039
• 全文大小：49K
• 年卷期：v.127,no.7(February 23, 2005)
• ISSN：1520-5126

文摘

A highly efficient, mild, practical, and catalytic multicomponent reaction for the synthesis of N-sulfonylamidines has been developed. This reaction has an extremely wide scope with regard to all three coupling components of alkyne, sulfonyl azide, and amine. Two plausible mechanistic pathways involving ketenimine or triazole intermediate are tentatively presented for the copper-catalyzed three-component coupling reactions.