Disposition of Doramectin Milk Residues in Lactating Dairy Sheep

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• 作者：Fernanda A. Imperiale ; Lourdes Mottier ; Juan M. Sallovitz ; Adriá ; n L. Lifschitz ; and Carlos E. Lanusse
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2003
• 出版时间：May 7, 2003
• 年：2003
• 卷：51
• 期：10
• 页码：3185 - 3190
• 全文大小：148K
• 年卷期：v.51,no.10(May 7, 2003)
• ISSN：1520-5118

文摘

Doramectin (DRM) is a broad spectrum macrocyclic lactone antiparasitic drug not approved for usein dairy animals. However, DRM and other endectocide compounds are widely used extra-label tocontrol endo- and ectoparasites in dairy sheep. The plasma disposition kinetics and the pattern ofDRM excretion in milk were characterized following its subcutaneous administration to lactating dairysheep. DRM concentration profiles were measured in plasma and milk samples after validation of aspecific HPLC-based methodology. DRM was detected between 1 h and 30 days post-treatment.DRM concentrations of 0.48 ng·mL^-1 (plasma) and 1.03 ng·mL^-1 (milk) were measured at 30 dayspost-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, andlarge concentrations were excreted in milk. The peak concentrations and total amount of DRMrecovered in milk (expressed as area under the concentration versus time curve) were 3-fold higherthan those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The longpersistence of DRM milk residues should be seriously considered before its extra-label use in dairyanimals is recommended.Keywords: Endectocides; doramectin; milk residues disposition; milk/plasma ratios; dairy sheep