Biomimetic Synthesis of Dimeric Metabolite Acremine G via a Highly Regioselective and Stereoselective Diels−Alder Reaction

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• 作者：Elias Arkoudis ; Ioannis N. Lykakis ; Charis Gryparis ; Manolis Stratakis
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：July 16, 2009
• 年：2009
• 卷：11
• 期：14
• 页码：2988-2991
• 全文大小：197K
• 年卷期：v.11,no.14(July 16, 2009)
• ISSN：1523-7052

文摘

The dimeric metabolite acremine G was synthesized featuring a highly regioselective and stereoselective Diels−Alder reaction between a TBS-protected hydroquinone diene and a structurally related alkenyl quinone. The major endo [4 + 2] adduct slowly transforms to acremine G by the atmospheric air under the deprotection conditions (in situ generated HF).