Catalytic Asymmetric Synthesis of Chiral 2-Vinylindole Scaffolds by Friedel–Crafts Reaction
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- 作者：Takayoshi AraiAkiko Tsuchida ; Tomoya Miyazaki ; Atsuko Awata
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：February 17, 2017
- 年：2017
- 卷：19
- 期：4
- 页码：758-761
- 全文大小：404K
- ISSN：1523-7052
文摘
A chiral bis(imidazolidine)pyridine (PyBidine)–Ni(OTf)2 complex smoothly catalyzed an asymmetric Friedel–Crafts reaction of 2-vinylindoles with nitroalkenes to give chiral indoles in a highly enantioselective manner while maintaining the 2-vinyl functionality. The chiral 2-vinylindoles offer unique chiral scaffolds for diverse transformations.