Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors
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- 作者：Stefania Butini ; Giuseppe Campiani ; Silvia Franceschini ; Francesco Trotta ; Vinod Kumar ; Egeria Guarino ; Giuseppe Borrelli ; Isabella Fiorini ; Ettore Novellino ; Caterina Fattorusso ; Marco Persico ; Nausi
- 刊名：Journal of Medicinal Chemistry
- 出版年：2010
- 出版时间：June 24, 2010
- 年：2010
- 卷：53
- 期：12
- 页码：4803-4807
- 全文大小：786K
- 年卷期：v.53,no.12(June 24, 2010)
- ISSN：1520-4804
文摘
As a continuation of our efforts to develop innovative ligands for D3, 5-HT1A, and 5-HT2A receptors with low propensity to block hERG channels, we propose a series bishetero(homo)arylpiperazines 5a−m as novel and potent multifunctional ligands characterized by low occupancy at D2 and 5-HT2C receptors.