Catalytic Hydrogenation of Esters. Development of an Efficient Catalyst and Processes for Synthesising (R)-1,2-Propanediol and 2-(l-Menthoxy)ethanol

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• 作者：Wataru Kuriyama ; Takaji Matsumoto ; Osamu Ogata ; Yasunori Ino ; Kunimori Aoki ; Shigeru Tanaka ; Kenya Ishida ; Tohru Kobayashi ; Noboru Sayo ; Takao Saito
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：16
• 期：1
• 页码：166-171
• 全文大小：338K
• 年卷期：v.16,no.1(January 20, 2012)
• ISSN：1520-586X

文摘

A ruthenium catalyst for the reduction of esters by hydrogenation has been developed. Processes for the hydrogenation of esters have also been developed for (R)-1,2-propanediol and 2-(l-menthoxy)ethanol. The catalyst shows good catalytic activity for the hydrogenation of esters in methanol. Methyl lactate was reduced at 30 掳C and gave turnover numbers (TON) up to 4000. The optical purity of the (R)-1,2-propanediol made by the hydrogenation of methyl (R)-lactate was higher than that via the asymmetric hydrogenation of hydroxyacetone. A hydrogenation process to replace the lithium aluminum hydride (LAH) reduction used in the production of 2-(l-menthoxy)ethanol was developed.