Stereocontrolled Total Synthesis of Hedyotol A

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• 作者：Yusuke Kawabe ; Ryo Ishikawa ; Yusuke Akao ; Atsushi Yoshida ; Makoto Inai ; Tomohiro Asakawa ; Yoshitaka Hamashima ; Toshiyuki Kan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 4, 2014
• 年：2014
• 卷：16
• 期：7
• 页码：1976-1979
• 全文大小：296K
• 年卷期：v.16,no.7(April 4, 2014)
• ISSN：1523-7052

文摘

The total synthesis of hedyotol A (1), a natural product isolated from Hedyotis lawsoniae (DC.) Wight et Arn. (Rubiaceae), was accomplished in a highly stereocontrolled manner. Key steps include an l-proline-catalyzed cross-aldol reaction and the biomimetic construction of a furofuran lignan skeleton through a quinomethide intermediate.