Asymmetric Epoxidation of α-Substituted Acroleins Catalyzed by Diphenylprolinol Silyl Ether

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• 作者：Bojan P. Bondzic ; Tatsuya Urushima ; Hayato Ishikawa ; Yujiro Hayashi
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：December 3, 2010
• 年：2010
• 卷：12
• 期：23
• 页码：5434-5437
• 全文大小：193K
• 年卷期：v.12,no.23(December 3, 2010)
• ISSN：1523-7052

文摘

Asymmetric epoxidation of α-substituted acroleins with hydrogen peroxide has been catalyzed by diphenylprolinol diphenylmethylsilyl ether to afford α-substituted-β,β-unsubstituted-α,β-epoxy aldehyde with excellent enantioselectivity and the generation of a chiral quaternary carbon center. The method was applied to a short synthesis of (R)-methyl palmoxirate.