Evelynin, a Cytotoxic Benzoquinone-Type retro-Dihydrochalcone from Tacca chantrieri

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• 作者：Jiangnan Peng ; Evelyn M. Jackson ; David J. Babinski ; April L. Risinger ; Gregory Helms ; Doug E. Frantz ; Susan L. Mooberry
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：September 24, 2010
• 年：2010
• 卷：73
• 期：9
• 页码：1590-1592
• 全文大小：105K
• 年卷期：v.73,no.9(September 24, 2010)
• ISSN：1520-6025

文摘

A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC₅₀ values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.