One-Pot Selective Homodimerization/Hydrogenation Strategy for Sequential Dicarba Bridge Formation

详细信息    查看全文

• 作者：James Burnley ; W. Roy Jackson ; Andrea J. Robinson
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：80
• 期：18
• 页码：9057-9063
• 全文大小：416K
• ISSN：1520-6904

文摘

The installation of interlocked dicarba bridges into peptide sequences requires the development of a regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt鈥揷arbonyl protected alkyne, and an alkene using metathesis and homogeneous hydrogenation catalysis.