Cerebrospinal Fluid Proteome of Patients with Acute Lyme Disease
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- 作者：Thomas E. Angel ; Jon M. Jacobs ; Robert P. Smith ; Mark S. Pasternack ; Susan Elias ; Marina A. Gritsenko ; Anil Shukla ; Edward C. Gilmore ; Carol McCarthy ; David G. Camp ; II ; Richard D. Smith ; H. Shaw Warren
- 刊名：Journal of Proteome Research
- 出版年：2012
- 出版时间：October 5, 2012
- 年：2012
- 卷：11
- 期：10
- 页码：4814-4822
- 全文大小：441K
- 年卷期：v.11,no.10(October 5, 2012)
- ISSN：1535-3907
文摘
During acute Lyme disease, bacteria can disseminate to the central nervous system (CNS), leading to the development of meningitis and other neurologic symptoms. Here we have analyzed pooled cerebrospinal fluid (CSF) allowing a deep view into the proteome for patients diagnosed with early disseminated Lyme disease and CSF inflammation. Additionally, we analyzed individual patient samples and quantified differences in protein abundance employing label-free quantitative mass spectrometry-based methods. We identified 108 proteins that differ significantly in abundance in patients with acute Lyme disease from controls. Comparison between infected patients and control subjects revealed differences in proteins in the CSF associated with cell death localized to brain synapses and others that likely originate from brain parenchyma.