4-Quinolone Alkaloids from Melochia odorata

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• 作者：Raquel C. Jadulco ; Christopher D. Pond ; Ryan M. Van Wagoner ; Michael Koch ; Osia G. Gideon ; Teatulohi K. Matainaho ; Pius Piskaut ; Louis R. Barrows
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：183-187
• 全文大小：316K
• ISSN：1520-6025

文摘

The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 渭M and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 渭M, respectively. The structures of the alkaloids were established by spectroscopic data interpretation.