The Scope and Limitation of Nickel-Catalyzed Aminocarbonylation of Aryl Bromides from Formamide Derivatives
详细信息 查看全文
- 作者：Youngshin Jo ; Jinhun Ju ; Jaehoon Choe ; Kwang Ho Song ; Sunwoo Lee
- 刊名：Journal of Organic Chemistry
- 出版年：2009
- 出版时间：August 21, 2009
- 年：2009
- 卷：74
- 期：16
- 页码：6358-6361
- 全文大小：760K
- 年卷期：v.74,no.16(August 21, 2009)
- ISSN：1520-6904
文摘
Nickel-catalyzed aminocarbonylation of aryl halides is described. A well-defined air-stable nickel−phosphite catalytic system (Ni(OAc)2·4H2O/phosphite 1) effectively promoted the aminocarbonylation of aryl bromides with a range of formamides to give the corresponding aryl amide products in moderate to good yields. The less hindered formamide required lower catalytic loading for full conversion and produced higher yields than the more hindered one. It also exhibited base-dependent activity toward formamides.