A Click Strategy for the Immobilization of MacMillan Organocatalysts onto Polymers and Magnetic Nanoparticles
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- 作者：Paola Riente ; Jagjit Yadav ; Miquel A. Peric脿s
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：July 20, 2012
- 年：2012
- 卷：14
- 期：14
- 页码：3668-3671
- 全文大小：288K
- 年卷期：v.14,no.14(July 20, 2012)
- ISSN：1523-7052
文摘
A chemically modified, first generation MacMillan imidazolidin-4-one has been anchored onto 1% DVB Merrifield resin and Fe3O4 (5.3 卤 1.4 nm) magnetic nanoparticles through copper-catalyzed alkyne azide cycloaddition (CuAAC) reactions. The resulting immobilized catalysts have been successfully used in the asymmetric Friedel鈥揅rafts alkylation of N-substituted pyrroles with 伪,尾-unsaturated aldehydes. The PS-supported catalyst (B) showed higher catalytic activity and enantioselectivity, while the MNP-supported one (A) showed higher recyclability and could be used in a sequential process with intermediate magnetic decantation.