Discovery and Optimization of Substituted 1-(1-Phenyl-1H-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics
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- 作者：Steve F. Poon ; David J. St. Jean ; Jr. ; Paul E. Harrington ; Charles Henley ; III ; James Davis ; Sean Morony ; Fred D. Lott ; Jeff D. Reagan ; Jenny Ying-Lin Lu ; Yuhua Yang ; Christopher Fotsch
- 刊名：Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：November 12, 2009
- 年：2009
- 卷：52
- 期：21
- 页码：6535-6538
- 全文大小：729K
- 年卷期：v.52,no.21(November 12, 2009)
- ISSN：1520-4804
文摘
Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure−activity relationships of various substituted heterocycles and their effects on the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.