Chlorinated Coumarins from the Polypore Mushroom Fomitopsis officinalis and Their Activity against Mycobacterium tuberculosis

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• 作者：Chang Hwa Hwang ; Birgit U. Jaki ; Larry L. Klein ; David C. Lankin ; James B. McAlpine ; Jos茅 G. Napolitano ; Nicole A. Fryling ; Scott G. Franzblau ; Sang Hyun Cho ; Paul E. Stamets ; Yuehong Wang ; Guido F. Pauli
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：October 25, 2013
• 年：2013
• 卷：76
• 期：10
• 页码：1916-1922
• 全文大小：295K
• 年卷期：v.76,no.10(October 25, 2013)
• ISSN：1520-6025

文摘

An EtOH extract of the polypore mushroom Fomitopsis officinalis afforded two new naturally occurring chlorinated coumarins, which were identified as the previously synthesized compounds 6-chloro-4-phenyl-2H-chromen-2-one (1) and ethyl 6-chloro-2-oxo-4-phenyl-2H-chromen-3-carboxylate (2). The structures of the two isolates were deduced by ab initio spectroscopic methods and confirmed by chemical synthesis. In addition, an analogue of each was synthesized as 7-chloro-4-phenyl-2H-chromen-2-one (3) and ethyl 7-chloro-2-oxo-4-phenyl-2H-chromen-3-carboxylate (4). All four compounds were characterized physicochemically, and their antimicrobial activity profiles revealed a narrow spectrum of activity with lowest MICs against the Mycobacterium tuberculosis complex.