Application of a Sequential Multicomponent Assembly Process/Huisgen Cycloaddition Strategy to the Preparation of Libraries of 1,2,3-Triazole-Fused 1,4-Benzodiazepines
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- 作者：James R. Donald ; Rebekah R. Wood ; Stephen F. Martin
- 刊名：ACS Combinatorial Science
- 出版年：2012
- 出版时间：February 13, 2012
- 年：2012
- 卷：14
- 期：2
- 页码：135-143
- 全文大小：484K
- 年卷期：v.14,no.2(February 13, 2012)
- ISSN：2156-8944
文摘
A strategy featuring a multicomponent assembly process followed by an intramolecular azide鈥揳lkyne dipolar (Huisgen) cycloaddition was implemented for the facile synthesis of three different 1,2,3-triazolo-1,4-benzodiazepine scaffolds. A diverse library of 170 compounds derived from these scaffolds was then created through N-functionalizations, palladium-catalyzed cross-coupling reactions, and several applications of 伪-aminonitrile chemistry.