Kinetic Resolution of Allylic Alcohols Using a Chiral Phosphine Catalyst

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• 作者：Edwin Vedejs and James A. MacKay
• 刊名：Organic Letters
• 出版年：2001
• 出版时间：February 22, 2001
• 年：2001
• 卷：3
• 期：4
• 页码：535 - 536
• 全文大小：36K
• 年卷期：v.3,no.4(February 22, 2001)
• ISSN：1523-7052

文摘

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The kinetic resolution of racemic allylic alcohols 3, 6, and 12-17 has been explored using the PBO catalyst 7 for activation of isobutyricanhydride. Trisubstituted allylic alcohols (12-15; 17) are the best substrates and react with an enantioselectivity of s = 32-82 at -40 f">C.

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