Methamphetamine Vaccines: Improvement through Hapten Design
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- 作者：Karen C. Collins ; Joel E. Schlosburg ; Paul T. Bremer ; Kim D. Janda
- 刊名：Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：April 28, 2016
- 年：2016
- 卷：59
- 期：8
- 页码：3878-3885
- 全文大小：427K
- 年卷期：0
- ISSN：1520-4804
文摘
Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic. Development of a vaccine targeting MA would provide a complementary strategy to existing behavioral therapies, but this has proven challenging. Herein, we describe optimization of both hapten design and formulation, identifying a vaccine that elicited a robust anti-MA immune response in mice, decreasing methamphetamine-induced locomotor activity.