An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life

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• 作者：Atsushi Kimishima ; Cody J. WenthurBin Zhou ; Kim D. Janda
• 刊名：ACS Chemical Biology
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：12
• 期：1
• 页码：36-40
• 全文大小：341K
• ISSN：1554-8937

文摘

Prescription opioids (POs) such as oxycodone and hydrocodone are highly effective medications for pain management, yet they also present a substantial risk for abuse and addiction. The consumption of POs has been escalating worldwide, resulting in tens of thousands of deaths due to overdose each year. Pharmacokinetic strategies based upon vaccination present an attractive avenue to suppress PO abuse. Herein, the preparation of two active PO vaccines is described that were found to elicit high-affinity antiopioid antibodies through a structurally congruent drug-hapten design. Administration of these vaccines resulted in a significant blockade of opioid analgesic activity, along with an unprecedented increase in drug serum half-life and protection against lethal overdose.