Catalyst-Controlled Regioselective Suzuki Couplings at Both Positions of Dihaloimidazoles, Dihalooxazoles, and Dihalothiazoles
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- 作者：Neil A. Strotman ; Harry R. Chobanian ; Jiafang He ; Yan Guo ; Peter G. Dormer ; Christina M. Jones ; Janelle E. Steves
- 刊名：Journal of Organic Chemistry
- 出版年：2010
- 出版时间：March 5, 2010
- 年：2010
- 卷：75
- 期：5
- 页码：1733-1739
- 全文大小：906K
- 年卷期：v.75,no.5(March 5, 2010)
- ISSN：1520-6904
文摘
Various dihaloazoles can be monoarylated at a single C−X bond with high selectivity via Suzuki coupling. By changing the palladium catalyst employed, the selectivity can be switched for some dihaloazoles, allowing for Suzuki coupling at the other, traditionally less reactive C−X bond. These conditions are applicable to coupling of a wide variety of aryl-, heteroaryl-, cyclopropyl-, and vinylboronic acids with high selectivities and enable the rapid construction of diverse arrays of diarylazoles in a modular fashion.