Elaboration of Sterically Hindered δ-Lactones through Ring-Closing Metathesis: Application to the Synthesis of the C1–C27 Fragment of Hemicalide
详细信息 查看全文
- 作者：Camille Lecourt ; Srikanth Boinapally ; Sabrina Dhambri ; Guillaume Boissonnat ; Christophe Meyer ; Janine Cossy ; François Sautel ; Georges Massiot ; Janick Ardisson ; Geoffroy Sorin ; Marie-Isabelle Lannou
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：December 16, 2016
- 年：2016
- 卷：81
- 期：24
- 页码：12275-12290
- 全文大小：761K
- ISSN：1520-6904
文摘
The synthesis of the C1–C27 fragment of hemicalide, a marine metabolite displaying a unique potent antiproliferative activity, has been accomplished. The synthetic approach highlights a remarkably efficient ring-closing metathesis reaction catalyzed by Nolan ruthenium indenylidene complexes to elaborate the highly substituted δ-lactone framework.