Anti-inflammatory and Antimalarial Meroterpenoids from the New Zealand Ascidian Aplidium scabellum

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• 作者：Susanna T. S. Chan ; A. Norrie Pearce ; Ana H. Januario ; Michael J. Page ; Marcel Kaiser ; Rene J. McLaughlin ; Jacquie L. Harper ; Victoria L. Webb ; David Barker ; Brent R. Copp
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：76
• 期：21
• 页码：9151-9156
• 全文大小：262K
• 年卷期：v.76,no.21(November 4, 2011)
• ISSN：1520-6904

文摘

Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2)鈥揇 (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A鈥揇 is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum.