Iminonitroso Diels-Alder Reactions for Efficient Derivatization and Functionalization of Complex Diene-Containing Natural Products

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• 作者：Fangzheng Li ; Baiyuan Yang ; Marvin J. Miller ; Jaroslav Zajicek ; Bruce C. Noll ; Ute Mö ; llmann ; Hans-Martin Dahse ; Patricia A. Miller
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：July 19, 2007
• 年：2007
• 卷：9
• 期：15
• 页码：2923 - 2926
• 全文大小：298K
• 年卷期：v.9,no.15(July 19, 2007)
• ISSN：1523-7052

文摘

A remarkably efficient method for derivatization of complex diene-containing natural products by using stabilized iminonitroso Diels-Alderreactions is described. Turimycin H3, ergosterol, reductiomycin, isoforocidin, colchicine and thebaine were found to react with nitrosopyridinesin a highly efficient regio- and stereoselective fashion. Preliminary bioactivity evaluations of turimycin cycloadducts are reported.