Conformational Preferences of Zampanolide and Dactylolide

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• 作者：Erik M. Larsen ; Matthew R. Wilson ; Jaroslav Zajicek ; Richard E. Taylor
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：15
• 期：20
• 页码：5246-5249
• 全文大小：264K
• 年卷期：v.15,no.20(October 18, 2013)
• ISSN：1523-7052

文摘

The solution conformation behavior of the macrolide core of microtubule-stabilizing agents (鈭?-zampanolide and (鈭?-dactylolide has been determined through a combination of high-field NMR experiments and computational modeling. Taken together, the results demonstrate that in solution both molecules exist as a mixture of three interconverting conformational families, one of which bears strong resemblance to zampanolide鈥檚 tubulin-bound conformation.