Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria
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- 作者：Margey Tadesse ; Morten B. Strø ; m ; Johan Svenson ; Marcel Jaspars ; Bruce F. Milne ; Veronika Tø ; rfoss ; Jeanette H. Andersen ; Espen Hansen ; Klara Stensvå ; g ; Tor Haug
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：November 5, 2010
- 年：2010
- 卷：12
- 期：21
- 页码：4752-4755
- 全文大小：170K
- 年卷期：v.12,no.21(November 5, 2010)
- ISSN：1523-7052
文摘
Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.