Enantioselective Synthesis of ,-Disubstituted-
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- 作者：Mukund P. Sibi ; Narayanasamy Prabagaran ; Sandeep G. Ghorpade ; and Craig P. Jasperse
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：October 1, 2003
- 年：2003
- 卷：125
- 期：39
- 页码：11796 - 11797
- 全文大小：64K
- 年卷期：v.125,no.39(October 1, 2003)
- ISSN：1520-5126
文摘
Highly diastereoselective and enantioselective addition of N-benzylhydroxylamine to imides 17 and 20-30 produces 
,
-trans-disubstituted N-benzylisoxazolidinones 19 and 31-41. These reactions proceed in 60-96% ee with 93-99% de's using 5 mol % of Mg(NTf2)2 and ligand 18. The product isoxazolidinones can be hydrogenolyzed directly to provide ,-disubstituted--amino acids.
,-trans-disubstituted N-benzylisoxazolidinones 19 and 31-41. These reactions proceed in 60-96% ee with 93-99% de's using 5 mol % of Mg(NTf2)2 and ligand 18. The product isoxazolidinones can be hydrogenolyzed directly to provide ,-disubstituted--amino acids.