Tandem RCM-Isomerization- Cyclopropanation Reactions

详细信息    查看全文

• 作者：Á ; lvaro Mallagaray ; Gema Domí ; nguez ; Ana Gradillas ; Javier P&eacute ; rez-Castells
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：February 21, 2008
• 年：2008
• 卷：10
• 期：4
• 页码：597 - 600
• 全文大小：80K
• 年卷期：v.10,no.4(February 21, 2008)
• ISSN：1523-7052

文摘

PACE=5>

A new triple tandem process has been discovered in which simple acyclic substrates can be transformed into bicyclic compounds via RCM-double bond isomerization-cyclopropanation. This process is catalyzed by second generation Grubb's catalyst without the requirement ofother reactives or additives. In addition, a one-pot RCM-isomerization reaction followed by cyclopropanation with CHCl₃/NaOH allows thesynthesis of products related to iNOS (nitric oxide synthase) inhibitors, which are currently under clinical evaluation.