Catalytic Enantioselective Approach to the Stereodivergent Synthesis of (+)-Lasubines I and II

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• 作者：Olga Garcí ; a Mancheñ ; o ; Ram&oacute ; n G&oacute ; mez Arrayá ; s ; Javier Adrio ; Juan C. Carretero
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：December 21, 2007
• 年：2007
• 卷：72
• 期：26
• 页码：10294 - 10297
• 全文大小：90K
• 年卷期：v.72,no.26(December 21, 2007)
• ISSN：1520-6904

文摘

GR ID=jo702076jn00002>A concise and efficient approach to the stereodivergentsynthesis of (+)-lasubines I and II is described. The keycommon intermediate is a chiral N-sulfonyl 2,3-dihydropyridone obtained by a novel Cu-catalyzed asymmetric formalaza-Diels-Alder reaction between N-tosyl aldimines andDanishefsky's diene.