Copper-Catalyzed Electrophilic Amination of Diorganozinc Reagents

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• 作者：Ashley M. Berman and Jeffrey S. Johnson
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：May 12, 2004
• 年：2004
• 卷：126
• 期：18
• 页码：5680 - 5681
• 全文大小：56K
• 年卷期：v.126,no.18(May 12, 2004)
• ISSN：1520-5126

文摘

The copper-catalyzed electrophilic amination of diorganozinc reagents employing O-acyl N,N-dialkyl hydroxylamine derivatives as aminating agents is described. This reaction offers a general method for the preparation of tertiary amines in high yields and is noteworthy for its convenience both in terms of reaction conditions employed (room temperature, images/entities/le.gif">1 h) and ease of product isolation (acid/base extractive workup).