Peptide Ligations Accelerated by N-Terminal Aspartate and Glutamate Residues

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• 作者：Gemma L. Thomas ; Yves S. Y. Hsieh ; Candy K. Y. Chun ; Zheng-Li Cai ; Jeffrey R. Reimers ; Richard J. Payne
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：September 16, 2011
• 年：2011
• 卷：13
• 期：18
• 页码：4770-4773
• 全文大小：766K
• 年卷期：v.13,no.18(September 16, 2011)
• ISSN：1523-7052

文摘

A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated.