Proton-Induced Reactivity of NO鈥?/sup> from a {CoNO}8 Complex
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- 作者：Melody A. Rhine ; Andria V. Rodrigues ; Ramona J. Bieber Urbauer ; Jeffrey L. Urbauer ; Timothy L. Stemmler ; Todd C. Harrop
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：September 10, 2014
- 年：2014
- 卷：136
- 期：36
- 页码：12560-12563
- 全文大小：279K
- ISSN：1520-5126
文摘
Research on the one-electron reduced analogue of NO, namely nitroxyl (HNO/NO鈥?/sup>), has revealed distinguishing properties regarding its utility as a therapeutic. However, the fleeting nature of HNO requires the design of donor molecules. Metal nitrosyl (MNO) complexes could serve as potential HNO donors. The synthesis, spectroscopic/structural characterization, and HNO donor properties of a {CoNO}8 complex in a pyrrole/imine ligand frame are reported. The {CoNO}8 complex [Co(LN4PhCl)(NO)] (1) does not react with established HNO targets such as FeIII hemes or Ph3P. However, in the presence of stoichiometric H+ 1 behaves as an HNO donor. Complex 1 readily reacts with [Fe(TPP)Cl] or Ph3P to afford the {FeNO}7 porphyrin or Ph3P鈺怬/Ph3P鈺怤H, respectively. In the absence of an HNO target, the {Co(NO)2}10 dinitrosyl (3) is the end product. Complex 1 also reacts with O2 to yield the corresponding CoIII-畏1-ONO2 (2) nitrato analogue. This report is the first to suggest an HNO donor role for {CoNO}8 with biotargets such as FeIII-porphyrins.