Functionalization of Peptides and Proteins by Mukaiyama Aldol Reaction

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• 作者：Jenefer Alam ; Thomas H. Keller ; Teck-Peng Loh
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：July 21, 2010
• 年：2010
• 卷：132
• 期：28
• 页码：9546-9548
• 全文大小：225K
• 年卷期：v.132,no.28(July 21, 2010)
• ISSN：1520-5126

文摘

The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C−C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.