Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

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• 作者：Guan-Young Jeong ; Raffaele Ricco ; Kang Liang ; Johanna Ludwig ; Jin-Oh Kim ; Paolo Falcaro ; Dong-Pyo Kim
• 刊名：Chemistry of Materials
• 出版年：2015
• 出版时间：December 8, 2015
• 年：2015
• 卷：27
• 期：23
• 页码：7903-7909
• 全文大小：362K
• ISSN：1520-5002

文摘

Functional bio-MOF hollow spheres with controlled size in the 35鈥?000 渭m range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.