Aerosol-Processed Thermosensitive Nanocomposites for Controlled Drug Release

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• 作者：Jeong Hoon Byeon ; Jang-Woo Kim
• 刊名：ACS Macro Letters
• 出版年：2014
• 出版时间：April 15, 2014
• 年：2014
• 卷：3
• 期：4
• 页码：369-373
• 全文大小：320K
• 年卷期：v.3,no.4(April 15, 2014)
• ISSN：2161-1653

文摘

In this study, an ambient-spark-produced iron (Fe)-nanoparticle-laden nitrogen gas was mixed with an atomized solution of N-isopropylacrylamide (NIPAM)-polydimethylsiloxane (PDMS). The Fe nanoparticles reacted with NIPAM-PDMS in the atomized droplets to form encapsulated Fe nanoparticles, i.e., Fe@NIPAM-PDMS nanocomposites, whose size distribution was unimodal (showing only a NIPAM-PDMS-like distribution, with the Fe distribution eliminated). By varying processing temperatures, it was possible to obtain Fe@NIPAM-PDMS nanocomposites with different sizes and morphologies. This is further attributed to the quantitative incorporation of Fe nanoparticles into atomized NIPAM-PDMS-doxorubicin (DOX) droplets. The Fe@NIPAM-PDMS-DOX nanocomposites released different amounts of DOX under a magnetothermal effect, which produced different levels of cytotoxic effects on the targeted HeLa cells. The thermosensitivity makes these nanocomposites an ideal candidate for important applications such as controlled drug delivery.