Anticancer Activity of Self-Assembled Molecular Rectangles via Arene鈥揜uthenium Acceptors and a New Unsymmetrical Amide Ligand
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- 作者：Anurag Mishra ; Hyunji Jung ; Jeong Woo Park ; Hong Kyeung Kim ; Hyunuk Kim ; Peter J. Stang ; Ki-Whan Chi
- 刊名：Organometallics
- 出版年：2012
- 出版时间：May 14, 2012
- 年：2012
- 卷：31
- 期：9
- 页码：3519-3526
- 全文大小：504K
- 年卷期：v.31,no.9(May 14, 2012)
- ISSN：1520-6041
文摘
Two new and large molecular rectangles 4 and 5 were synthesized from two different arene鈥搑uthenium [Ru2(渭-畏4-C2O4)(MeOH)2(畏6-p-PriC6H4Me)2][O3SCF3]2 (2) and [Ru2(p-cymene)2(donq)(OH2)2][O3SCF3]2 (donq = 5,8-dioxydo-1,4-naphthaquinonato) (3) acceptors and a new unsymmetrical N-(4-(pyridin-4-ylethynyl)phenyl) isonicotinamide (1) donor ligand. X-ray crystallography of 4 confirmed a molecular rectangle. The 1H NMR spectra of both rectangles 4 and 5 showed a mixture of two structural, head-to-tail (HTT) and head-to-head (HTH), type isomers in a 1:1 ratio. The cytotoxicities of both rectangles have been established against Colo320 (colorectal cancer), A549 (lung cancer), MCF-7 (breast cancer), and H1299 (lung cancer) human cancer cell lines. The cytotoxicity of rectangle 5 was found to be considerably stronger against all cancer cell lines than that of the reference drug cisplatin.