Acuminolide A: Structure and Bioactivity of a New Polyether Macrolide from Dinoflagellate Dinophysis acuminata

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• 作者：Buyng Su Hwang ; Heong Seop Kim ; Wonho Yih ; Eun Ju Jeong ; Jung-Rae Rho
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：October 17, 2014
• 年：2014
• 卷：16
• 期：20
• 页码：5362-5365
• 全文大小：245K
• ISSN：1523-7052

文摘

Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated on the basis of ROESY correlations and J-based analysis. In contrast to the other well-known toxins that were isolated, 1 showed no cytotoxicity against four cancer cell lines but caused potent stimulation of actomyosin ATPase activity.