Synthesis of Terminal Allenes via a Copper-Catalyzed Decarboxylative Coupling Reaction of Alkynyl Carboxylic Acids
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- 作者：Jeongah Lim ; Jinseop Choi ; Han-Sung Kim ; In Seon Kim ; Kye Chun Nam ; Jimin Kim ; Sunwoo Lee
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：January 4, 2016
- 年：2016
- 卷：81
- 期：1
- 页码：303-308
- 全文大小：375K
- ISSN：1520-6904
文摘
Synthesis of terminal allenes via a copper-catalyzed decarboxylative coupling reaction was developed. Aryl alkynyl carboxylic acid, paraformaldehyde, and dicyclohexylamine were reacted with CuI (20 mol %) in diglyme at 100 °C for 2 h to produce the terminal allene in moderate to good yields. The method showed good functional group tolerance.